US researchers find specific changes in the blood of the patient suffering from two types of deadly cancer pancreatic cancer and mesothelioma cancer. This allows to diagnose the doctor to cancer at earlier stages.
By Somalogic developed scanning technology, the company researchers say early signs of pancreatic cancer and a sort of mesothelioma lung cancer in people who diagnosed, are but not receiving treatment for the disease called can recognize. "At this time the cancer at an advanced stage recognized the possibility of treatment minimally, has been," said Rachel Ostroff, Director of clinical research on Somalogic Inc., who presented the results at a meeting of the American Association for cancer research in Denver recently.
Pancreas cancer without symptoms strikes and recognized recently at an advanced stage. The National Cancer Institute says pancreatic cancer is rarely curable. If the cancer of the pancreas (localized), cure rates will be higher. It is only slightly less than 20 percent so, usually with best wishes in all cases.
For patients with cancer, which is still less than 2 cm, with no spread to lymph nodes, up to five years can save at least cancer surgery patients. This possibility could reach 18-24 percent.
The pancreas is a body, shaped like a tube sponges length about 6 inches, which is found behind the stomach. The pancreas produces enzymes and hormones, including insulin. Pancreatic enzymes help digest food in the small intestine during insulin to control blood sugar levels. Enzymes and hormones necessary for the maintenance of the body to work properly.
Men are twice as likely to attack this disease. Pancreatic cancer is more common in smokers in smokers. People who suffer a greater risk chronic pancreatic disease and those who are probably suffering from long-term diabetes (especially women).
Meanwhile mesothelioma is a form of cancer that is often caused by malignant cells that develop in the mesothelium, a protective lining that covers most of the institutions. The most common is the pleura (outer lining of lungs and internal chest wall) but can also occur in the pericardium or feed of vaginalis.
Most of mesothelioma, caused by frequent exposure to asbestos particles affected. Washing of a family member who had worked with asbestos can also at risk of developing mesothelioma. In contrast to lung cancer, and no mapping between mesothelioma and smoking.
Symptoms of mesothelioma are shortness of breath due to the pleural fluid (liquid between the lungs and the chest wall) or wall pain in the chest, and also because the excess weight. "This aggressive cancer detection at earlier stages on patients that will identify early treatment, their quality of life and a chance to restore can improve", he said.
Pancreatic cancer is relatively rare, but it is the fourth largest cause of cancer related deaths in the United States (US). Mesothelioma caused by asbestos, killed around 15 thousand and 20 thousand people per year worldwide.
In the October NEC Corporation Japan, to invest$ 5 million as part of a strategic partnership with Somalogic, headquartered in Colorado, technology, aimed to develop detection of disease by the protein in a drop of blood tests. A number of genetic material that is bound to proteins depends aptamers - Somalogic tests. Somalogic technology rather freeze the molecule to certain proteins have improved.
For the study, researchers tested the blood sample two types of cancer, and those who suffer company patients in the control group joined, which similarly have a condition with symptoms such as pancreatitis and cancers such as pulmonary fibrosis.
The team used computer models to distinguish significant differences in biology and biological markers, the blood samples from cancer patients with which to find that about cancer.
For both types of cancer the team found a biological marker of high accuracy in detecting all kinds of cancer, who said Ostroff. They are also very specific in the sense that are able to properly remove people who suffer from cancer. Now biomarkers that the results are correct and are reproduced by other studies to ensure in diagnostic tests may need to be confirmed. "It's easy to find biomarkers" Ostroff said at the meeting. "It is hard to do validation on you."
Ostroff said his team a number of factors, the false positive results, such as how long an example can trigger on the shelf should be placed, watch to be tested before. "We have tested these parameters to ensure that we observe biomarker disease,", he said.
